Pre-Clinical Research Services

Value proposition

Test/monitor target engagement or off-target effects in the brain. Help determine effective and safe doses. Define the therapeutic window in humans.

Key Services

​​Detection & quantification of  biomarkers within NDEs. ​

Customization of exosome-based assay for specific targets. ​

Biomarker assay analytical validation and clinical incorporation. ​

Services list

Target engagement biomarker discovery, development, and validation. ​

Pathway engagement biomarker discovery, development, and validation. ​

Off-target/adverse event/safety biomarker discovery, development, and validation.

Why Choose NeuroDex

At NeuroDex, we are committed to advancing the field of neurological diagnostics through cutting-edge biomarker discovery and innovative testing solutions. Our proprietary technologies and research capabilities enable us to deliver precise and reliable insights for early disease detection, monitoring treatment efficacy, and advancing therapeutic research.

Operational Excellence

NeuroDex's operational excellence is built on rigorous quality standards, including GLP and CLIA compliance, ensuring reliable, reproducible, and high-quality biomarker analysis.

Personalized Insights

NeuroDex's personalized insights approach delivers customized biomarker panels designed to precisely detect and monitor disease markers, supporting targeted research and improved patient outcomes.

Scientific Precision

NeuroDex's scientific precision is driven by advanced isolation and detection techniques that ensure accurate biomarker identification, supporting reliable diagnostics and robust research outcomes.

Collaborative Approach

NeuroDex's collaborative approach involves partnering with clinical and research teams to develop tailored biomarker solutions, fostering seamless integration and impactful research outcomes.

Pre-clinical research is the essential first step in turning a scientific idea into a therapy that can safely help real patients. Before any new drug or treatment is tested in humans, researchers must understand how a disease works, how a potential therapy behaves in the body, and whether it shows early signs of safety and effectiveness. This stage creates the evidence base that guides smarter decisions and reduces risk later in development — and that is exactly where Pre-Clinical Research Services play a critical role.

Pre-Clinical Research Services

Our Pre-Clinical Research Services are designed to bridge the gap between discovery and clinical trials. By combining controlled laboratory studies, validated disease models, and modern analytical tools, Pre-Clinical Research Services help researchers and innovators move from hypothesis to proof-of-concept with confidence.

Pre-Clinical Research Services can include both in vitro testing (cell-based assays) and in vivo research using animal models that closely reflect human biology. These models allow scientists to explore disease progression, evaluate therapeutic candidates, and monitor their effects across multiple systems — long before human trials begin. Through Pre-Clinical Research Services, early-stage results become measurable, reliable, and actionable.

Turning complex science into clear answers with Pre-Clinical Research Services

One of the greatest values of Pre-Clinical Research Services is the ability to measure outcomes in a controlled environment. For example, in studies of neurodegenerative conditions such as Alzheimer’s disease, researchers may use genetically modified models to examine how neurodegeneration develops over time. With Pre-Clinical Research Services, it becomes possible to test potential therapeutic agents and evaluate how they impact critical biomarkers, brain structure, and neurological function — often supported by advanced imaging tools that reveal changes that are not visible through traditional methods.

The findings produced through Pre-Clinical Research Services directly shape the design of later human clinical trials, helping teams select the most promising compounds, define appropriate endpoints, and reduce avoidable failure risks. In this way, Pre-Clinical Research Services ensure that the transition from lab to clinic is smoother, faster, and scientifically stronger.

Technology-driven precision through Pre-Clinical Research Services

Pre-clinical research has evolved rapidly in recent years — especially through the use of biomarker profiling, high-throughput screening, and AI-driven data interpretation. Modern Pre-Clinical Research Services now include advanced analytics that improve data quality and predictive accuracy. In many cases, Pre-Clinical Research Services leverage machine learning models that can analyze large datasets to identify patterns, predict outcomes, and spotlight high-potential drug candidates faster than traditional approaches.

This technology-enabled precision makes Pre-Clinical Research Services a key advantage for companies seeking efficient and reliable drug development. By using Pre-Clinical Research Services, development teams can make better decisions earlier — saving time, reducing waste, and improving the probability of clinical success.

Pre-Clinical Research Services designed for evolving health challenges

Modern healthcare is constantly changing — from antibiotic resistance to emerging viral threats. That means research must be agile and scalable. Pre-Clinical Research Services help organizations respond quickly to evolving disease landscapes by adapting models, methods, and evaluation strategies. During the COVID-19 pandemic, researchers rapidly adjusted testing protocols and pre-clinical models to evaluate vaccines and therapeutics at unprecedented speed — demonstrating why agile Pre-Clinical Research Services are now a core requirement for future readiness.

Pre-Clinical Research Services

Collaboration and compliance supported by Pre-Clinical Research Services

Breakthroughs rarely happen in isolation. Academic institutions, biotech firms, and pharmaceutical companies frequently collaborate to combine expertise, resources, and infrastructure. Pre-Clinical Research Services play a central role in enabling collaboration by standardizing research workflows, data interpretation, and validation practices. When multiple partners contribute to a pipeline, Pre-Clinical Research Services ensure results are aligned, comparable, and reproducible.

Equally important is regulatory alignment. Agencies such as the FDA provide guidelines that define what evidence is required before a therapy can move into human trials. Strong Pre-Clinical Research Services ensure that studies are conducted with high integrity, in line with safety expectations, and supported by robust documentation. In other words, Pre-Clinical Research Services reduce regulatory risk while strengthening scientific credibility.

 

Biomarker Discovery Solutions

NeuroDex provides advanced biomarker discovery solutions that integrate seamlessly into clinical workflows. Our neuron-derived extracellular vesicle (NDE) panels enable precise disease detection, monitoring, and treatment evaluation. Validated under GLP and CLIA standards, our solutions support personalized diagnostics, enhance patient care, and optimize therapeutic strategies.

Regulatory Compliance

Clinical Trial Support

Enhanced Diagnostic Accuracy

Personalized Monitoring

01

Parkinson's disease and synucleopathy

*a-syn biomarker, novel biomarker discovery

02

ALS

*TDP43 biomarker, novel biomarker discovery

03

Alzheimer's disease

*Tau/pTau, A-syn, biomarkers, novel biomarker discovery

04

Neuroinflamation

*NF-kB biomarker, novel biomarker discovery

05

Autophagy, Brain injury

*LC3 biomarker, novel biomarker discovery