Biotech Blog(Page 7)

Biotech Blog

Illustration of neurons releasing extracellular vesicles into the bloodstream, with increased phosphorylated Akt, mTOR and GSK3β as a blood-based readout of GLP-1 CNS target engagement
Did Your GLP-1 Drug Reach the Brain? Measuring CNS Target Engagement from a Blood Sample
GLP-1 drugs are being tested in Alzheimer's and Parkinson's, but did they reach the brain? How neuron-derived...
Alpha-Synuclein Blood Test for Prodromal Parkinson’s
Parkinson's Starts a Decade Before Diagnosis. Can Blood Find It?
A prevention trial in Parkinson’s disease has a recruitment problem that site activation cannot...
Patient care in Parkinson's disease and alpha-synuclein biomarker research.
Beyond Alpha-Synuclein: Measuring Neuronal Function to Stratify Parkinson’s Patients
Parkinson’s drug development has more targets than ever. Programs now aim at the lysosome, the mitochondrion,...
Preclinical CNS biomarker translation from a mouse model to human blood using brain-derived extracellular vesicles for biomarker analysis.
Carrying a Biomarker Signal From Animal Model to First-in-Human
When a research institute re-tested roughly 100 compounds that had looked promising in a widely used...
Banked plasma samples stored in a biorepository freezer for a blood biomarker feasibility study
Before You Add a Blood Biomarker to Your Trial, Test It on Samples You Already Have
A sponsor writes a blood biomarker into a Phase II protocol on the strength of published cohorts. The...
Laboratory analysis of samples in a multi-site CNS biomarker study
Turnaround, Batching, and Data Deliverables in a Multi-Site CNS Biomarker Study
A Phase II neurodegeneration trial enrolls across fourteen sites. Blood draws are scheduled at baseline,...
Schematic neuron representing blood-based CNS biomarkers and companion diagnostic development
Companion Diagnostic Development for Blood-Based CNS Biomarkers
Companion Diagnostic Development for Blood-Based CNS Biomarkers In oncology, a companion diagnostic usually...
Laboratory researcher entering assay data beside sample tubes during blood biomarker analysis for LATE
LATE and Mixed Pathology: Separating Copathology Signals in Blood
Enroll a few hundred older adults with amnestic mild cognitive impairment and a positive amyloid blood...
Where AI Is Actually Working in Neuroscience Today
Where AI Is Actually Working in Neuroscience Today — and Where It Is Overhyped
Artificial intelligence has become the default framing for almost every neuroscience headline. Foundation...
Blood biomarker variability illustrated through serial blood sampling and longitudinal biomarker measurements
More Draws, Better Decisions: Blood Biomarker Variability in Longitudinal Trial Design
A lumbar puncture schedule caps a trial at a handful of CSF timepoints per participant. A blood draw...
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